Director

Director: F.G. Issa, MD, PhD
Associate Professor
Sydney, Australia

Publications: 

  1. Chaufour, X., F. Issa, C. Sullivan, C. Mclachlan, G. Unger. A fully-automated environmental chamber for examination of long-term effects of intermittent hypoxia on medium-size animals. Jpn. J. Physiol. 49:207-211 (1999). [Abstract]
  2. Schachter, L.M., C.M. Salome, A.M. Roberts, F.G. Issa, C.E. Sullivan, A.J. Woolcock. Change in lung volume with change in posture from upright to supine is not related to changes in airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 157;A515 (1998).
  3. Schachter, L.M., T. Kirjavainen, F.G. Issa, C.E. Sullivan, A.J. Woolcock. Inspiratory resistance and its association with inspiratory symptoms in asthmatics during airway challenge. Am. J. Respir. Crit. Care Med. 157;A671 (1998).
  4. McNamara, F., F. G. Issa, C. E. Sullivan. Arousal pattern following central and obstructive breathing abnormalities in infants and children. J. Appl. Physiol. 81;2651-2657 (1996) [Abstract]
  5. Vazquez, J.C., Masuda, A., Hajduk, E., Iyer, A., Tanguay, S., Flemons, W., Whitelaw, W., Issa, F.G. and Remmers, J.E. Hospital and home digital monitoring of sleep disordered breathing using arterial oxygen saturation and snoring sound. Am. J. Respir. Crit. Care Med. 153;A870 (1996).
  6. Issa, F.G. and Mitchell, I. Nocturnal respiratory disturbances of infancy and subsequent breathing pattern during childhood. In: Sleep Breathing Disorders and Sudden Infant Death Syndrome. National Center of Neurology and Psychiatry, Ministry of Health & Welfare, Japan, pp 135-141 (1995).
  7. Issa, F.G. and Porostocky, S. Gustatory stimulation of the oropharynx fails to induce swallowing during sleep. Gastroenterology 107;879-892 (1994). [Abstract]
  8. Issa, F.G. and Porostocky, S. Control of ventilation during continuous swallowing. Am. J. Respir. Crit. Care Med. 150;1274-1278 (1994). [Abstract]
  9. Issa, F.G., Porostocky, S and Feroah, T. Effect of sleep and sighing on upper airway resistance in the mongrel dog. J. Appl. Physiol. 76:856-861 (1994). [Abstract]
  10. Isono, S., Feroah, T.R., Hadjuk, E.A., Morrison, D.L., Launois, S.H., Issa, F.G., Whitelaw, W.A. and Remmers, J.E. Anatomy of the pharyngeal airway in sleep apneics: separating anatomic factors from neuromuscular factors. Sleep 16:S80-84 (1994).
  11. Issa, F.G., Remmers, J.E. and Hadjuk, E. Detection of sleep-disordered breathing by computerized oximetry. Am. Rev. Respir. Dis. 149:A181(1994).
  12. Issa, F.G. and Porostocky, S. Effect of continuous swallowing on respiration. Respir. Physiol. 95:181-193 (1994). [Abstract]
  13. Issa, F.G. and S. Porostocky. Augmentation of genioglossus muscle activity during partial paralysis of the parasternal muscle. Am. Rev. Respir. Dis. 147:A948 (1993).
  14. Issa, F.G. and S. Porostocky. Control of ventilation during swallowing. Am. Rev. Respir. Dis. 147:A162 (1993).
  15. Issa, F.G. and S. Porostocky. Upper airway resistance during sighing in the awake and sleeping dog. Am. Rev. Respir. Dis. 147:A950 (1993).
  16. Rimmer, K.P., Golar, S.D. , Issa F.G. and Whitelaw, W.A. Response to inspiratory resistive loads in patients with amyotrophic lateral sclerosis. Am. Rev. Respir. Dis. 147:A960 (1993).
  17. Launois, S.H., Feroah, T.R., Campbell, W.N., Issa, F.G. , Morrison, D., Whitelaw, W.A. and J.E. Remmers. Site of pharyngeal narrowing predicts outcome of surgery for obstructive sleep apnea. Am. Rev. Respir. Dis. 147:182-189 (1993). [Abstract]
  18. Issa, F.G. and Bitner, S. Effect of route of breathing on the ventilatory and arousal responses to hypercapnia in awake and sleeping dogs. J. Physiol. (London) 465:615- 628 (1993). [Abstract]
  19. Issa, F.G. and Porostocky, S. Effect of sleep on changes in breathing pattern accompanying sigh breaths. Respir. Physiol. 93:175-187 (1993). [Abstract]
  20. Issa, F.G., Morrison, D., Hadjuk,E., Iyer, R., Feroah, T. and Remmers, J. Digital monitoring of sleep disordered breathing using snoring sound and arterial oxygen saturation. Am. Rev. Respir. Dis. 148:1023-1029 (1993). [Abstract]
  21. Issa, F.G. Effect of clonidine in obstructive sleep apnea. Am. Rev. Respir. Dis. 145:435-439 (1992). [Abstract]
  22. Issa, F.G. and J.E. Remmers. Identification of a subsurface area in the ventral medulla sensitive to local changes in PCO2. J. Appl. Physiol. 72:439-446 (1992). [Abstract]
  23. Issa, F.G. and S. Bitner. Restructuring of sleep and reversal of respiratory muscle hypotonia during REM sleep following bilateral phrenicotomy. Neurosci. Lett. 139:231-233 (1992). [Abstract]
  24. Issa, F.G., D. Morrison, E. Hajduk, A. Iyer, W. Whitelaw, T. Feroah, and J. Remmers. Digital monitoring of sleep apnea using SaO2 and snoring signals. Am. Rev. Respir. Dis. 145:A722 (1992).
  25. Launois, S.H., Isono, S., Morrison, D.L., Feroah, T.R., Issa, F.G., Whitelaw,W.A. and Remmers, J.E. Static mechanics of the hypotonic nasopharynx in patients with obstructive sleep apnea during sleep. Am. Rev. Respir. Dis. 145:A210 (1992).
  26. Issa, F.G. Effect of clonidine in obstructive sleep apnea. Am. Rev. Respir. Dis. 143:A589 (1991).
  27. Issa, F.G. The ventilatory response to hypercapnia: effect of sleep state and route of breathing. Am. Rev. Respir. Dis. 143:A797 (1991).
  28. Issa, F.G. The arousal response to hypercapnia: effect of sleep state and route of breathing. Am. Rev. Respir. Dis. 143:A797 (1991).
  29. Remmers, J.E., Issa, F.G., and Suratt, P.M. Sleep and respiration, J. Appl. Physiol. 68:1286-1289 (1990).
  30. Remmers, J.E. and Issa, F.G. Indications and rationale for treatment of sleep- disordered breathing in older people. In: The Treatment of Sleep Disorders of Older People. Bethesda, Maryland, pp 55-57 (1990).
  31. Bye, P.T.P, Ellis, E.R., Issa, F.G., Donnelly, P.M. and Sullivan, C.E. Respiratory failure and sleep in neuromuscular disease. Thorax 45:241-247 (1990).[Abstract]
  32. Issa, F.G., Suratt, P.M. and Remmers, J.E. (eds). Progress in Clinical and Biological Research: Sleep and Respiration, Wiley-Liss, Inc., New York, Volume 345 (1990).
  33. Issa, F.G. and Remmers J.E. Central chemoreceptive elements in the medullary ventral surface. Am. Rev. Respir. Dis. 141:379 (1990).
  34. Issa, F.G. and Bell, S. Determinants of CPAP in patients with sleep apnea. Am. Rev. Respir. Dis. 141:862 (1990).
  35. Issa, F.G. and Remmers, J.E. Pathophysiology and treatment of obstructive sleep apnea. Current Pulmonol. 10:327-352 (1989).
  36. Issa, F.G., Szeto, E., Lauff, D. and Sullivan, C.E. Genioglossus and breathing responses to airway occlusion in dogs: effect of sleep and route of occlusion. J. Appl. Physiol. 64:543-549 (1988). [Abstract]
  37. Issa, F.G. and Remmers, J.E. Localization of a medullary area sensitive to changes in CO2 in in-vitro brainstem-spinal cord preparation of newborn rats. Soc. Neurosci Abstr. 14:935 (1988).
  38. Issa, F.G., McNamara, S.G. and Sullivan, C.E. Arousal responses to airway occlusion in sleeping dogs: comparison of nasal and tracheal occlusions. J. Appl. Physiol. 62:1832-1836 (1987). [Abstract]
  39. Sullivan, C.E., Issa, F.G., Ellis, E., Bruderer, J., McCauley, V., Bye, P.T., Grunstein, R. and Costas, L.J. Treatment of cardio-respiratory disturbances during sleep. Interdiscipl. Topics Gerontol. 22:47-67 (1987).
  40. Weil, J.V., Cherniack, N.S., Dempsey, J.A., et al. National Heart, Lung and Blood Institute, National Institute of Health Workshop: Respiratory Disorders of Sleep. Pathophysiology, clinical implications, and therapeutic approaches. Am. Rev. Respir. Dis. 136:755-761 (1987).
  41. Issa, F.G., Grunstein, R., Bruderer, J., Costas, L., McCauley, V., Berthon-Jones, M. and Sullivan, C.E. Five years experience with home nasal continuous positive airway pressure therapy for the obstructive sleep apnea syndrome. In: Sleep Related Disorders and Internal Diseases. J.H. Peter, T. Podszus and P. von Wichert (eds.), Springer-Verlag, Heidelberg, pp 360-365 (1987).
  42. Issa, F.G. and Sullivan, C.E. The immediate effects of nasal continuous positive airway pressure treatment on sleep pattern in patients with the obstructive sleep apnea syndrome. Electroencephalogr. Clin Neurophysiol. 63:10-17 (1986). [Abstract]
  43. Issa, F.G. and Sullivan, C.E. Reversal of central sleep apnea using nasal CPAP. Chest 90:165-171 (1986). [Abstract]
  44. McNamara, S.G., Issa, F.G., Szeto, E. and Sullivan, C.E. Influence of negative pressure applied to the upper airway on the breathing pattern in unanesthetized awake dogs. Respir. Physiol. 65:315-329 (1986). [Abstract]
  45. Goh, A.S.F., Issa, F.G. and Sullivan, C.E. Upper airway dilating forces during wakefulness and sleep in dogs. J. Appl. Physiol. 61:2148-2155 (1986). [Abstract]
  46. Sullivan, C.E. and Issa, F.G. Obstructive sleep apnea. Clin. Chest Med. 6:633-650 (1985). [Abstract]
  47. Issa, F.G. and Sullivan, C.E. Respiratory muscle activity and thoraco-abdominal motion during acute episodes of asthma in sleep. Am. Rev. Respir. Dis. 132:999-1004 (1985). [Abstract]
  48. Issa, F.G., Costas, L.V., Berthon-Jones, M., McCauley, V.J., Bruderer, J. and Sullivan, C.E. Nasal CPAP treatment for obstructive sleep apnea: long-term experience with 117 patients. Am. Rev. Respir. Dis. 131:108 (1985).
  49. Bye, P.T.B., Ellis, E.R., Donnelly, P.D., Issa, F.G. and Sullivan, C.E. Role of sleep in the development of respiratory failure in neuromuscular disease. Am. Rev. Respir. Dis. 131:108 (1985).
  50. Issa, F.G. and Sullivan, C.E. The response to total airway occlusion during sleep in patients with obstructive sleep apnea. Proc. Aust. Physiol. Pharmacol. Soc. 15:77 (1985).
  51. Sullivan, C.E., Issa, F.G., Berthon-Jones, M., McCauley, V.B. and Costas, L.J.V. Home treatment of obstructive sleep apnea with continuous positive airway pressure applied through a nose mask. Bull. Eur. Physiopath. Respir. 20:49-54 (1984).[Abstract]
  52. Issa, F.G. and Sullivan, C.E. Upper airway closing pressure in obstructive sleep apnea. J. Appl. Physiol. 57:520-527 (1984). [Abstract]
  53. Issa, F.G. and Sullivan, C.E. Upper airway closing pressure in snorers. J. Appl. Physiol. 57:528-535 (1984). [Abstract]
  54. Bye, P.T.P., Issa, F.G., Berthon-Jones, M. and Sullivan, C.E. Studies of oxygenation during sleep in patients with interstitial lung disease. Am. Rev. Respir. Dis. 129:27-32 (1984). [Abstract]
  55. Sullivan, C.E., Issa, F.G., Berthon-Jones, M. and Saunders, N.A. Pathophysiology of sleep apnea. In: Sleep and Breathing. N.A. Saunders and C.E. Sullivan (eds.), Marcel Dekker, Inc. N.Y., pp 299-364 (1984).
  56. Sullivan, C.E., Berthon-Jones, M. and Issa, F.G. Nocturnal nasal airway pressure for sleep apnea. N. Engl. J. Med. 309:112 (1983).
  57. Issa, F.G. and Sullivan, C.E. Arousal and breathing responses to airway occlusion in healthy sleeping adults. J. Appl. Physiol. 55:1113-1119 (1983). [Abstract]
  58. Sullivan, C.E., Berthon-Jones, M. and Issa, F.G. Remission of severe obesity- hypoventilation syndrome after short-term treatment during sleep with nasal continuous positive airway pressure. Am. Rev. Respir. Dis. 128:177-181 (1983). [Abstract]
  59. Berthon-Jones, M., Issa, F.G., and Sullivan, C.E. Acute upward shift in ventilatory response to CO2 after reversal of obstructive sleep apnea by pneumatic splinting. Aust. NZ. J. Med. 12:224 (1982).
  60. Sullivan, C.E., Issa, F.G. and Berthon-Jones, M. Reduced severity of obstructive sleep apnea following long-term treatment by continuous positive airway pressure applied through the nose. Aust. NZ J. Med. 12:224 (1982).
  61. Issa, F.G., Berthon-Jones, M. and Sullivan, C.E. Reversal of heavy and habitual snoring by continuous positive airway pressure applied through the nares. Aust. NZ J. Med. 12:225 (1982).
  62. Sullivan, C.E., Berthon-Jones, M. and Issa, F.G. Treatment of obstructive sleep apnea with continuous positive airway pressure applied through the nose. Am. Rev. Respir.Dis. 125:107 (1982).
  63. Lindsay, D.A., Issa, F.G. and Sullivan, C.E. Mechanisms of sleep desaturation in chronic airflow limitation studied with nasal continuous positive airway pressure. Am. Rev. Respir. Dis. 125:112 (1982).
  64. Issa, F.G. and Sullivan, C.E. Alcohol, snoring and sleep apnea. J. Neurol. Neurosurg. Psychiatry 45:353-359 (1982). [Abstract]
  65. Sullivan, C.E., Issa, F.G., Berthon-Jones, M. and Eves, L. Reversal of obstructive sleep apnea by continuous positive airway pressure applied through the nares. Lancet i:862-865 (1981). [Abstract]
  66. Sullivan, C.E. and Issa, F.G. Pathophysiological mechanisms in obstructive sleep apnea. Sleep 3:235-246 (1980).